A Collaborative Research Center of Physicians, Researchers, Executives, and Innovators

MESH Innovation and Operations Research Center (MESH IO)

MESH IO is a unique inter-disciplinary research Center sitting within the MESH Incubator. IO spans Mass General Brigham, Harvard Medical and Harvard Business School and is comprised of specialty leaders, including physicians and executives, in innovation and operations in healthcare. This creative marriage of both innovation and operations researchers is dedicated to investigating key aspects of business in healthcare through original research and thought-leading papers for the medical community. The group is comprised of faculty and executives from different specialties, including medicine, radiology, emergency medicine, surgery and more.

Core Group

Marc D. Succi, MD | Sanjay Saini, MD | Joshua Hirsch, MD |  Ali S. Raja, MD MBA MPH | Ben White, MD | Ray Liu, MD | Michael S. Gee, MD PhD | Michael H. Lev, MD | Tarik Alkasab, MD | Tommy An, MD | Min Lang, MD | Arya Rao | Grant Rigney | Alexander King | Soham Ghoshal | Michael Hood, MD | Joel Samuel, MD | John Kim | Mciahel Pang | Chau Vo, MD | David Whitehead, MD MBA | Bruno Panzarini, MD | Haan Razak | Will Ge | Peter Zheng | Alex Chan | Anthony Fraga | Ottavia Zattra | Hyeon Ju Song | Jean Filo | Jowa Shi | Cameron Young | Natalie Baker | Husayn Ramji | Taylor Zabel

Select Peer-Reviewed Publications (Since 2020)

  1. Young CC, Enichen E, Rivera C, Auger CA, Grant N, Rao A, Succi MD. Diagnostic Accuracy of a Custom Large Language Model on Rare Pediatric Disease Case Reports. Am J Med Genet A. 2024 Sep 13; e63878. PMID: 39268988.
  2. Mazurek MH, Abruzzo AR, King AH, Koranteng E, Rigney G, Lie W, Razak S, Gupta R, Mehan WA, Lev MH, Hirsch JA, Buch K, Succi MD. Implementation of a Survey Spine MR Imaging Protocol for Cord Compression in the Emergency Department: Experience at a Level 1 Trauma Center. AJNR Am J Neuroradiol. 2024 Sep 09; 45(9):1378-1384. PMID: 38702066
  3. Young CC, Enichen E, Rao A, Succi MD. Racial, ethnic, and sex bias in large language model opioid recommendations for pain management. Pain. 2024 Sep 06. PMID: 39283333.
  4. Succi MD. Rogues, Inertia, and the Dogma of Innovation in Health Care. J Am Coll Radiol. 2024 Oct; 21(10):1549-1551. PMID: 39243950.
  5. Succi MD, Rao A, Gee MS, Coburn C, Brink JA. Empowering Radiology’s Future: A Proposed Leadership and Innovation Framework for a Radiology Department. J Am Coll Radiol. 2024 Aug 01. PMID: 39096944.
  6. Gowda V, Zioze DG, Succi MD. Board Composition and Corporate Coherence: Lessons for the Radiology Community. J Am Coll Radiol. 2024 Aug 01. PMID: 39096945.
  7. Davis N, El-Said E, Fortune P, Shen A, Succi MD. Transforming Healthcare Landscapes: The Lever of Radiology Research & Innovation on Emerging Markets Poised for Aggressive Growth. J Am Coll Radiol. 2024 Aug 01. PMID: 39096946.
  8. Miller AS, Beagles CB, Kaur MN, Marano AA, Hu S, Ghoshal S, Dey T, Coon D, Succi MD. Temporary Declines and Demand Resurgence: Gender-Affirming Surgery Volume and Complication Trends During and After the COVID-19 Pandemic. Aesthetic Plast Surg. 2024 Jul 11. PMID: 38992249.
  9. Russo MV, Di Capua J, Som A, Smith AD, Laroia ST, Succi MD. Building a Career in Radiology Innovation: a primer for trainees and first-time innovators to act on opportunities. J Am Coll Radiol. 2024 Jun 25. PMID: 38936587.
  10. Mazurek MH, Abruzzo AR, King AH, Koranteng E, Rigney G, Lie W, Razak S, Gupta R, Mehan WA, Lev MH, Hirsch JA, Buch KA, Succi MD. Implementation of a Survey Spine Magnetic Resonance Imaging Protocol for Cord Compression in the Emergency Department: Experience at a Level-1 Trauma Center. AJNR Am J Neuroradiol. 2024 May 13. PMID: 38702066.
  11. Rao A, Kim J, Lie W, Pang M, Fuh L, Dreyer KJ, Succi MD. Proactive Polypharmacy Management Using Large Language Models: Opportunities to Enhance Geriatric Care. J Med Syst. 2024 Apr 18; 48(1):41. PMID: 38632172.
  12. Rigney GH, King AH, Chung J, Ghoshal S, Jain A, Shi Z, Razak S, Hirsch JA, Lev MH, Buch K, Succi MD. Trends in non-focal neurological chief complaints and CT angiography utilization among adults in the emergency department. Intern Emerg Med. 2024 Mar 21. PMID: 38512433.
  13. Ghoshal S, Stovall N, King AH, Miller AS, Harris MB, Succi MD. Orthopaedic Surgery Volume Trends During the COVID-19 Pandemic and Post-Vaccination Era: Implications for Healthcare Planning. J Arthroplasty. 2024 Mar 19. PMID: 38513749.
  14. Ryan ET, Succi MD, Paras ML, Klontz EH. Case 4-2024: A 39-Year-Old Man with Fever and Headache after International Travel. N Engl J Med. 2024 Feb 08; 390(6):549-556. PMID: 38324489.
  15. Liu DS, Mazurek MH, Whitehead DC, Hood MC, Choi P, Gupte A, Ottensmeyer MP, Fintelmann FJ, Uppot RN, Andriole KP, Gee MS, Brink JA, Succi MD. A Novel Design-Thinking, Hospital Innovation Core Certificate Curriculum for Radiologists and Trainees: Creation, Implementation, and Multiyear Results. Acad Radiol. 2024 Feb; 31(2):417-425. PMID: 38401987.
  16. Koranteng E, Rao A, Flores E, Lev M, Landman A, Dreyer K, Succi M. Empathy and Equity: Key Considerations for Large Language Model Adoption in Health Care. JMIR Med Educ. 2023 Dec 28; 9:e51199. PMID: 38153778.
  17. Mallipeddi NV, Chandra J, Succi MD. A strategy to incentivize innovation in the health care system: the innovation RVU. Nat Biotechnol. 2023 Oct; 41(10):1485-1487. PMID: 37828282.
  18. Russo M, Di Capua J, Anlage A, Bendre H, Kusner J, Lieberman G, Jang S, Irani Z, Arellano RS, Sutphin PD, Smolinski-Zhao S, Daye D, Kalva SP, Succi MD, Som A, Thabet A. Preventing inadvertent drain removal using a novel catheter securement device. Sci Rep. 2023 09 26; 13(1):16130. PMID: 37752177; PMCID: PMC10522644.
  19. Rao A, Dreyer KJ, Succi MD. Reply to Letter to the Editor: Evaluating ChatGPT as an Adjunct for Radiologic Decision-Making. J Am Coll Radiol. 2023 Aug 31. PMID: 37659452.
  20. Rao A, Pang M, Kim J, Kamineni M, Lie W, Prasad AK, Landman A, Dreyer K, Succi MD. Assessing the Utility of ChatGPT Throughout the Entire Clinical Workflow: Development and Usability Study. J Med Internet Res. 2023 08 22; 25:e48659. PMID: 37606976; PMCID: PMC10481210.
  21. Rao A, Kim J, Kamineni M, Pang M, Lie W, Dreyer K, Succi MD. Evaluating GPT as an Adjunct for Radiologic Decision Making: GPT-4 Versus GPT-3.5 in a Breast Imaging Pilot. JACR. 2023 June 21.
  22. Blythe JA, Flores EJ, Succi MD. Justice and Innovation in Radiology. J Am Coll Radiol. 2023 Jun 12. PMID: 37315912.
  23. Yang E, Li MD, Raghavan S, Deng F, Lang M, Succi MD, Huang AJ, Kalpathy-Cramer J. Transformer versus traditional natural language processing: how much data is enough for automated radiology report classification? Br J Radiol. 2023 May 25; 20220769. PMID: 37162253.
  24. Succi MD, Cheng D, Andriole KP, Fintelmann FJ, Flores EJ, Zhang HM, Gee MS, Coburn CM, Brink JA. Integrating a healthcare innovation bootcamp into an international medical conference to democratize innovation learning. Nat Biotechnol. 2023 Apr; 41(4):579-581. PMID: 37069384.
  25. Succi MD, Ghoshal S, Cheng D, Alvarez C, Bredellaa MA. A Scalable Mentoring Web Platform Deployed in a Large Academic System: Pilot Implementation. J Am Coll Radiol. 2023 Mar 31. PMID: 37003309.
  26. Rao A, Kim J, Kamineni M, Pang M, Lie W, Succi MD. Evaluating ChatGPT as an Adjunct for Radiologic Decision-Making. medRxiv. 2023 Feb 07. PMID: 36798292.
  27. Rao A, Pang M, Kim J, Kamineni M, Lie W, Prasad AK, Landman A, Dreyer KJ, Succi MD. Assessing the Utility of ChatGPT Throughout the Entire Clinical Workflow. medRxiv. 2023 Feb 26. PMID: 36865204; PMCID: PMC9980239.
  28. Cheng D, Ghoshal S, Zattra O, Flash M, Lang M, Liu R, Lev MH, Hirsch JA, Saini S, Gee MS, Succi MD. Trends in oncological imaging during the COVID-19 pandemic through the vaccination era. Cancer Med. 2023 Feb 12. PMID: 36775966.
  29. Andy H Lee, Yosef Berlyand, Sayon Dutta, Marc D Succi, Jonathan D Sonis, Brian J Yun, Ali S Raja, Anand Prabhakar, Joshua J Baugh.CT utilization in evaluation of skin and soft tissue extremity infections in the ED: Retrospective cohort study. The American Journal of Emergency Medicine, 2023.
  30. Joowon Chung, Doyun Kim, Jongmun Choi, Sehyo Yune, Kyungdoo Song, Seonkyoung Kim, Michelle Chua, Marc D. Succi, John Conklin, Maria G. Figueiro Longo, Jeanne B. Ackman, Milena Petranovic, Michael H. Lev & Synho Do . Prediction of oxygen requirement in patients with COVID-19 using a pre-trained chest radiograph xAI model: efficient development of auditable risk prediction models via a fine-tuning approach. Nature Scientific Reports. 2022.
  31.  Alex Chan, MD *, Moses J. . Flash *, Teddy Guo, Ottavia Zattra, Okechi Boms, Marc D. Succi, MD *, Joshua A. Hirsch, MD *. Trends in academic productivity amongst radiologists during the COVID-19 pandemic. JACR. 2022.
  32. An TJ, Kim N, King AH, Panzarini B, Little BP, Goiffon RJ, Meyersohn N, Garrana S, Stowell J, Saini S, Ghoshhajra BB, Hedgire S, Succi MD. Trends in coronary calcium score and coronary CT angiography imaging volume during the COVID-19 pandemic. Curr Probl Diagn Radiol. 2022 Nov 18. PMID: 36473800.
  33. Figueiro Longo MG, Vuylsteke P, Tan CO, Soons JAM, Avery L, Succi MD, Baliyan V, Pourvaziri A, Xu L, Chonde D, Lev M, Cant J, Gupta R. “All-in-one” window/level whole-body computed tomography scan – A faster way to evaluate trauma cases. Am J Emerg Med. 2022 Oct 07; 62:62-68. PMID: 36272188
  34. Yosef Berlyand, John Anthony Fraga, Marc D Succi, Brian J Yun, Andy Hung-Yi Lee, Joshua J Baugh, David Whitehead, Ali S Raja, Anand M Prabhakar. Impact of iodinated contrast allergies on emergency department operations. The American Journal of Emergency Medicine, 2022
  35. Ghoshal S, Rigney G, Cheng D, Brumit R, Gee, MS, Hodin, R, Lillemoe, KA, Levine W, Succi, MD. Institutional Surgical Response and Associated Volume Trends Throughout the COVID-19 Pandemic and Postvaccination Recovery Period. JAMA Netw Open. 2022;5(8):e2227443. doi:10.1001/jamanetworkopen.2022.27443
  36. Azan Z. Virji, Abraham Z. Cheloff, Soham Ghoshal, Baily Nagle, Teddy Z. Guo, Michael H. Lev, Ali S. Raja, Michael S. Gee, Marc D. Succi. Analysis of self-initiated visits for cervical trauma at urgent care centers and subsequent emergency department referral. 2022 Aug 10
  37. Badawy M, Solomon N, Elsayes KM, Soliman M, Diaz-Marchan P, Succi MD, Pourvaziri A, Lev MH, Mellnick VM, Gomez-Cintron A, Revzin MV. Nonaccidental Injury in the Elderly: What Radiologists Need to Know. Radiographics. 2022 Jul 08; 220017. PMID: 35802501. Invited Commentary: Elder Abuse and Neglect—Radiologists Ready to Join the Identification and Referral Team 
  38. Kim D, Chung J, Choi J, Succi MD, Conklin J, Longo MGF, Ackman JB, Little BP, Petranovic M, Kalra MK, Lev MH, Do S. Accurate auto-labeling of chest X-ray images based on quantitative similarity to an explainable AI model. Nat Commun. 2022 Apr 06; 13(1):1867. PMID: 35388010.
  39. Boms O, Shi Z, Mallipeddi N, Chung JJ, Marks WH, Whitehead DC, Succi MD. Integrating innovation as a core objective in medical training. Nat Biotechnol. 2022 Mar; 40(3):434-437. PMID: 35296823.
  40. Ali Pourvaziri, Anand K Narayan, David Tso, Vinit Baliyan, McKinley Glover IV, Bernardo C Bizzo, Bashar Kako, Marc D Succi, Michael H Lev, Efren J Flores. Imaging Information Overload: Quantifying the burden of interpretive and non-interpretive tasks for CT angiography for aortic pathologies in emergency radiology. Current Problems in Diagnostic Radiology. 2022.
  41. Lang M, Cartmell S, Tabari A, Briggs D, Pianykh O, Kirsch J, Cauley S, Lo WC, Risacher S, Filho AG, Succi MD, Rapalino O, Schaefer P, Conklin J, Huang SY. Evaluation of the Aggregated Time Savings in Adopting Fast Brain MRI Techniques for Outpatient Brain MRI. Acad Radiol. 2021 Oct 08. PMID: 34635436.
  42. Ottavia Zattra, Anthony Fraga, Nancy Lu, Michael S Gee, Raymond W Liu, Michael H Lev, James A Brink, Sanjay Saini, Min Lang, Marc D Succi. Trends in cancer imaging by indication, care setting, and hospital type during the COVID‐19 pandemic and recovery at four hospitals in Massachusetts. Cancer Med. 2021 Aug 6. doi: 10.1002/cam4.4183. Epub ahead of print. PMID: 34355873.
  43. Succi MD, Chang K, An T, Rosman DA, Raja AS, Gee MS, Lev MH, Liu RW, Saini S, Brink JA. Increased per-patient imaging utilization in an emergency department setting during COVID-19. Clin Imaging. 2021;80:77-82. doi:10.1016/j.clinimag.2021.06.003
  44. Li MD, Wood PA, Alkasab TK, Lev MH, Kalpathy-Cramer J, Succi MD. Automated tracking of emergency department abdominal CT findings during the COVID-19 pandemic using natural language processing. Am J Emerg Med. 2021 May 27;49:52-57. doi: 10.1016/j.ajem.2021.05.057. Epub ahead of print. PMID: 34062318; PMCID: PMC8154187.
  45. Chan AK, Wu C, Cheung A, Succi MD. Characterization of an open access medical news platform readership during the COVID-19 pandemic. J Med Internet Res. 2021 Apr 16. doi: 10.2196/26666. Epub ahead of print. PMID: 33866307.
  46. Jan Witowski, Jongmoon Choi, Soomin Jeon, Doyun Kim, Joowon Chung, John Conklin, Maria Figueiro Gabriela Longo, Marc D. Succi, Synho Do. MarkIt: A collaborative artificial intelligence annotation platform leveraging blockchain for medical imaging research. 2021.
  47. D’Alessandro HA, Gilman MD, Kambadakone A, Lamb LR, Lehman CD, Mendoza DP, Succi MD. Unilateral Lymphadenopathy After COVID-19 Vaccination: A Practical Management Plan for Radiologists Across Specialties. J Am Coll Radiol. 2021 Mar 04. PMID: 33713605.
  48. Snyder A, Jang S, Nazari IS, Som A, Flores EJ, Succi MD, Little BP. Google search volume trends for cancer screening terms during the COVID-19 pandemic. J Med Screen. 2021 Mar 04; 969141321999426. PMID: 33663240.
  49. Chonde, Pourvarazi, Williams, McGowan, Moskos, Alavarez, Narayan, Daye, Flores, Succi. RadTranslate™: An AI-powered intervention for urgent imaging to enhance care equity for patients with limited English proficiency during the COVID-19 pandemic. 2021
  50. Lang, Yeung, McLoud, Petranovic, Flores, Som, Shepard, Prabhakar, Saini, Succi*, Little*. Operational challenges of a low-dose CT lung cancer screening program during the COVID-19 pandemic. 2020. *co-senior authors.
  51. Guitron, Piankyh, Succi, Lang, Brink. COVID-19: Recovery Models for Radiology Departments. Journal of the American College of Radiology. 2020.
  52. Lang M, Yeung T, Mendoza DP, Flores EJ, Som A, Lang AL, Pianykh OS, Lee SI, Saini S, Little BP, Succi MD. Imaging Volume Trends and Recovery During the COVID-19 Pandemic: A Comparative Analysis Between a Large Urban Academic Hospital and Its Affiliated Imaging Centers. Acad Radiol. 2020 Aug 15. PMID: 32830030.
  53. Succi MD, Zamarron BF, Fintelmann FJ, Andriole KP, Ottensmeyer MP, Whitehead DC, Harris GJ, McLoud TC, Brink JA, Gee MS, Uppot RN. Initial Experience Integrating a Hands-On Innovation Curriculum Into a Radiology Residency Program and Department. J Am Coll Radiol. 2020 May 16. PMID: 32428436.
  54. Succi MD, Yun BJ, Rao S, Rao S, Gottumukkala RV, Glover M, White BA, Lev MH, Raja AS, Prabhakar AM. Turning around cancer: Oncology imaging and implications for emergency department radiology workflow. Am J Emerg Med. 2020 02; 38(2):317-320. PMID: 31759782.